Gastrocytoprotective properties of cryopreserved placenta extract in combined action of low temperatures and inhibition of cyclooxygenase

Introduction. Non-steroidal anti-inflammatory drugs (NSAIDs) are ranked first among the world's effective and analgesic with anticipated side effects. That is why prevention of development adverse reactions associated NSAIDs, in particular, those related to their ulcerogenicity, remains a serious global problem. Aims. To characterize mechanisms gastrocytoprotective activity cryopreserved placenta combined action low temperatures diclofenac sodium. Material methods. The study was performed on 42 male rats weighing 200-220 g. Acute sodium-induced gastropathy reproduced by single injection latter at dose 50 mg/kg. content malonic dialdehyde, catalase activity, prostaglandin synthase nitrogen monoxide metabolites homogenates gastric mucosa were determined spectrophotometric method. Results discussion. showed that prophylactic administration placental cryoextract increased antioxidant system as demonstrated an elevated 40.0% compared control rats. Modulation antioxidant-prooxidant homeostasis believed be one principal placenta. This shown statistically significant (p < 0.05) 2.2-fold increase index group gastropathy. Administration found two times rats, which would reduce iatrogenic deficiency mucosa. Also, level (by 70.1%) Conclusions. prooxidant-antioxidant contents leading gastroprotective extract